Commentary on Watson and Crick Dna Discovery Essay Example for Free

Commentary on Watson and twirl Dna Discovery sampleIn their 1953 Nature publication, Watson and Crick announced their landmark discovery DNA exists in the form of a right handed, three-dimensional double spiral. They described their DNA model as two DNA fibrils affiliated by hydrogen bonds between complementary bases. Adenine bases ar always paired with thymines, and cytosines argon always paired with guanines. Watson and Crick identified the anti-parallel configuration of DNA strands each 5 end of one strand is paired with the 3 end of its complementary strand. Nucleotides are linked to each opposite by their orthophosphate groups, which bind the 3 end of one sugar to the 5 end of the next sugar. Nitrogenous bases are available to participate in hydrogen bonding. This important morphologic feature correlates with function that would soon be discovered the bases have sites available to form hydrogen bonds with the proteins that play vital roles in the restitution and demonstration of DNA. Since its inception, these features of the Watson and Crick model remain the same today. This enduring credibility is amazing, considering that many scientific research findings are drastically modified over time.In this typography, the two scientists claim their model to be radically various in order to strongly set it apart from the DNA structural model that was competitively proposed by Pauling and Corey, and also by Fraser a triple helix with bases positioned emergeward. Watson and Crick rejected the triple helix model, criticizing that the jut bases would leave the negatively charged phosphates positioned inward and towards each other. This could not be the correct structure beca drill the hatred of negative charges would blow apart the helix. Therefore, Watson and Crick knew it was the bases, not the phosphates, which were positioned inward and linked by hydrogen bonds. Their structural hypothesis was consistent with Chargaffs research as well as the x-ray data.The intrigue of this paper cannot solely be attributed to its clear and simple presentation of a landmark discovery. Watson and Crick were indeed scientific pioneers, but they could never have drawn correct conclusions about DNA structure without considering data and hypotheses of other scientists. Chargaffs discovery about DNA base proportions as well as Franklins essential X-ray crystallography data made it possible for Watson and Crick to derive the three-dimensional, double-helical model for the structure of DNA. Although other scientists came close, Watson and Crick were the ones who got it right.Watson and Cricks model suggested the structure correlated with function It has not escaped our notice that the peculiar(prenominal) pairing we have postulated suggests a possible copying mechanism for the genetic material. The process of DNA replication was unknown at the time. By investigation of its function in the replication process, scientists were able to find out m ore about the more complex levels of DNA structure, which Watson and Cricks model fails to predict. Today, we know that in that respect are different DNA structures in prokaryotes and eukaryotes. In eukaryotic cells, DNA in the nucleus is tightly packaged into chromosomes. The chromosomes form when DNA wraps around an 8-histone core to build the nucleosomes that make up chromosomes. Therefore, the double helix model of DNA is only relevant when DNA is in a replication stage. The model does not provide any information about important, higher level complexities of DNA structure.Our present accord of retentiveness and utilization of a cells genetic information has been possible because of Watson and Cricks discovery. For example, understanding DNA has led us to new, successful avenues for medical research and treatment of diseases. We are able to use genetic screening for disease, and we have a better understanding of disease mutation, as in the flu virus. Also, our knowledge of DN As structure and function has made tissue matching possible for patients receiving transplants.